Our mission is to ensure the generation of accurate and precise findings.
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At Auxiliary Biosciences, our mission is clear: “Listening for Needs; Delivering Solutions.” This dedication is embodied by our Science and Technology (S&T) organization. Our team consists of highly skilled scientists and professionals who excel at navigating the complexities of the pharmaceutical landscape. Acting as an extension of your own team, we apply our deep scientific expertise to help accelerate your innovation and progress through the drug discovery and development continuum. From concept to candidate, we aim to reduce costs, shorten timelines, and guide you to better outcomes. Their commitment to addressing the unmet needs of patients fuels our innovative solutions and exceptional results.
We offer custom services in the following research areas:
Enantioselective synthesis is crucial for accessing biologically active small molecules in the pharmaceutical industry. At Auxiliary Biosciences, we specialize in custom synthesis of chiral molecules through both racemic material separation and modern asymmetric synthesis methodologies. Our team of experts excels in catalyst screening and multi-step synthesis, catering to quantities ranging from a few milligrams to multi kilo scale.
Our asymmetric synthesis services include:
• Asymmetric Induction: Leveraging cutting-edge techniques for precise control over stereochemistry.
• Organocatalysis: Employing small organic molecules to facilitate stereoselective reactions.
• Enzymatic Reactions: Specialized in reductions, esterases, and decarboxylases for high specificity and efficiency.
• Stereo-Differentiating Reactions: Advanced methods for achieving high stereocontrol in complex molecules.
• Desymmetrization: Transforming symmetric molecules into chiral compounds with high enantioselectivity.
• Chiral Pool: Utilizing naturally occurring chiral molecules as starting materials.
Join us at Auxiliary Biosciences to leverage our expertise and enhance your pharmaceutical research with our comprehensive asymmetric synthesis services.
Heterogeneous Catalysis
Heterogeneous catalysts, particularly those incorporating transition metals, can finely tune reaction selectivity and accelerate reaction rates. They offer significant advantages, such as easy separation and reusability, enhancing the efficiency and sustainability of chemical processes.
Building on our extensive in-house catalyst inventory, we continue to research, design, develop, and manufacture a variety of catalysts to support our projects:
• Customized and Specialized Catalysts: Tailored to specific needs.
• Catalyst Screening: Comprehensive evaluation for optimal performance.
• Heterogeneous Pd Catalysts: Effective in coupling reactions and Hydrogenation.
• Other Possibilities: Continuously exploring new catalyst technologies to meet evolving industry needs.
Biocatalysis
Enzymes, the central catalysts in biosystems, facilitate chemical reactions under mild conditions (temperature, pH, etc.) and exhibit great selectivity, particularly enantioselectivity. Their catalytic function can also be adjusted through mutations. At Auxiliary Biosciences, we offer:
• Library Enzyme Screening: Identifying the best enzymes for specific reactions.
• Process Development: Tailoring biocatalytic processes for optimal performance.
Discover how Auxiliary Biosciences leverages advanced catalysis technologies, including novel possibilities, to enhance the efficiency and sustainability of chemical processes.
At Auxiliary Biosciences, scientists with over 15 years of experience design and synthesize compound libraries. Specializing in both target-focused and diverse libraries, the team has successfully delivered ranging from 20 to 600 compounds, either as standalone projects or in collaboration with clients from the pharmaceutical, agrochemical, animal health, and other related industries. Experts combine deep knowledge in library design and synthesis, solid and solution-phase synthesis, and compound management to accelerate the discovery of effective molecules. Comprehensive support for compound registration and processing is tailored to meet client needs. A dedicated internal team focuses on synthesizing scaffolds for library projects.
Our state-of-the-art laboratories are equipped with advanced infrastructure for synthesis, purification, and analysis, including high-performance liquid chromatography (HPLC) purification systems and liquid chromatography-mass spectrometry (LC-MS) analysis capabilities, ensuring precise and efficient results.
Usage of the isotope labeled compounds are becoming crucial and are being used tremendously especially in finding the chemical sequential pathways, either in a reaction or in a biological cell. At Auxiliary Biosciences, while employing the appropriate labeled reagents and modern methodology we synthesize and characterize (NMR and MS) the desired products, labeled with isotopes 2H, 13C, and 15N etc.
Auxiliary Biosciences offers specialized synthesis services for nucleosides and nucleotides, aiding partners in drug discovery and development. Our expertise extends to the creation of novel nucleosides, nucleotides, and their conjugations, including oligonucleotides. We provide a range of services such as:
• Synthesis of novel nucleoside/nucleotide and nucleoside amidites.
• Conjugation of oligonucleotides with peptides or proteins.
• Advanced derivatization chemistry involving biotin, fluorescent dyes, enzymes, and bespoke compounds.
Auxiliary Biosciences provides comprehensive heterocyclic synthesis services to support our partners in the discovery of novel molecules for medical, veterinary, and agricultural applications. We can synthesize heterocyclic compounds on scales ranging from milligrams to kilograms, utilizing advanced analytical techniques like NMR and LC-MS for characterization.
Our offerings encompass:
• Synthesis of heterocyclic rings
• Functionalization of heterocyclic compounds is carried out using diverse reactions, including those catalyzed by transition metals, photoredox reactions, electrochemical processes, and enzymatic transformations.
• Utilization of heterocyclic compounds as latent groups for the preparation of other functional groups.
These capabilities enable us to assist our partners in achieving their goals of developing innovative and effective solutions.
Auxiliary Biosciences offers expert aliphatic chemistry solutions for diverse applications. Our services include:
• Aliphatic Compound Synthesis: Customized for pharmaceuticals, agrochemicals, and industrial uses.
• Custom Reactions: Expertise in hydrogenation, oxidation, halogenation etc...
• Scale-Up: From milligram to kilogram production.
• Analytical Support: Advanced characterization and purity analysis.
Choose us for reliable, high-quality aliphatic chemistry services, backed by an expert team and innovative solutions.
At Auxiliary Biosciences, we specialize in synthesizing a wide range of lipid products to support drug discovery and development, from preclinical to clinical stages. Our expertise ensures the successful design, synthesis, and scale-up of lipid compounds tailored to your needs.
Our services include:
• Design of Novel Lipid Synthesis Routes: We develop new synthetic routes for lipid targets of any complexity, ensuring efficient and scalable processes.
• Data Generation and Interpretation: We generate and interpret critical data to ensure the safe and effective scale-up of lipid synthesis.
• Custom Lipid Synthesis: We offer custom synthesis of lipid products on scales ranging from milligrams to hundreds of grams, including ionizable lipids, neutral lipids, hybrid sterols, phospholipids, sphingolipids, PEGylated lipids, glycerolipids, anionic lipids, and cationic lipids.
• Lipid Nanoparticle Formulation: Our team formulates lipid nanoparticles, providing advanced solutions for drug delivery systems.
Auxiliary Biosciences is committed to delivering high-quality lipid synthesis services, ensuring that our partners achieve their research and development goals efficiently and effectively.
Auxiliary Biosciences specializes in custom peptide synthesis, providing comprehensive support for your research and development projects. Our team leverages advanced synthesis methods and meticulous purification processes to deliver peptides tailored to your specific needs.
Our Expertise Includes:
• Custom Peptide Design: We design peptides ranging from 2 to 20+ amino acids, including both linear and cyclic configurations, tailored to your project specifications.
• Advanced Synthesis Techniques: Our team specializes in solid-phase and liquid-phase peptide synthesis, as well as combined solution and on-resin peptide synthesis, to suit different research needs and scales.
• Scalable Production: Our capabilities extend from milligram to gram scales, accommodating everything from small pilot studies to larger research projects.
• Rigorous Purification and Analysis: Our dedicated purification team ensures that each peptide reaches high purity and quality standards using state-of-the-art analytical techniques.
• Custom Modifications: We offer a range of modifications including labeling and conjugation to enhance the utility and application of our peptides.
Rely on Auxiliary Biosciences for expertly synthesized peptides that propel your scientific investigations forward.